A Study of LY2880070 in Participants With Advanced or Metastatic Cancer
NCT02632448 · Status: COMPLETED · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 229
Last updated 2025-05-02
Summary
The main purpose of this 3-part study is to evaluate the safety and efficacy of the study drug known as LY2880070 in participants with advanced or metastatic solid tumors.
Conditions
- Solid Tumors
- Colorectal Cancer
- Breast Cancer
- Ovarian Cancer
- Colon Cancer
- Rectal Cancer
- Neoplasms
- Endometrial Cancer
- Soft Tissue Sarcoma
- Triple Negative Breast Cancer
- Pancreas Cancer
- Pancreatic Cancer
Interventions
- DRUG
-
LY2880070
Capsules
- DRUG
-
50 to 600 milligrams per square meter of body surface area (mg/m2)
Sponsors & Collaborators
-
Esperas Pharma Inc.
lead OTHER
Principal Investigators
-
Email: [email protected] · Esperas Pharma Inc.
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- BASIC_SCIENCE
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2016-05-16
- Primary Completion
- 2025-04-14
- Completion
- 2025-04-14
- FDA Drug
- Yes
Countries
- United States
- Canada
- Croatia
- Poland
Study Locations
More Related Trials
-
A Study of Merestinib (LY2801653) in Japanese Participants With Advanced or Metastatic Cancer
NCT03027284 ·Status: COMPLETED ·Phase: PHASE1
-
LY3023414 and Prexasertib in Metastatic Triple-negative Breast Cancer
NCT04032080 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of LY2835219 (Abemaciclib) in Combination With Therapies for Breast Cancer That Has Spread
NCT02057133 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Randomized Phase 2 Study of Atezolizumab and Entinostat in Patients With aTN Breast Cancer With Phase 1b Lead In
NCT02708680 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Study of RC48-ADC Administered Intravenously to Patients With HER2-Positive Metastatic Breast Cancer With or Without Liver Metastases
NCT03500380 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2/PHASE3
-
A Study of LY3007113 in Participants With Advanced Cancer
NCT01463631 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of LY4050784 in Participants With Advanced or Metastatic Solid Tumors
NCT06561685 ·Status: RECRUITING ·Phase: PHASE1
-
A Phase I Study of a Therapeutic Vaccine Candidate in Patients With Localized Breast Cancer at High-Risk of Relapse
NCT02364492 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Test How Well Different Doses of BI 3820768 Are Tolerated by People With Advanced Cancer (Solid Tumours)
NCT07306559 ·Status: RECRUITING ·Phase: PHASE1
-
A Study to Evaluate the Safety, Tolerability, and Efficacy of BMS-986523 Alone and in Combination With Anti-Cancer Agents in Participants With Advanced Solid Malignancies
NCT07223047 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Phase 1 Study of LY2874455 in Participants With Advanced Cancer
NCT01212107 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of Emibetuzumab in Combination With Ramucirumab (LY3009806) in Participants With Advanced Cancer
NCT02082210 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Study of LY2875358 in Participants With Advanced Cancer
NCT01287546 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of Prexasertib (LY2606368) in Participants With Advanced Cancer
NCT02778126 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of LY2875358 in Japanese Participants With Advanced Cancer
NCT01602289 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase II Study of Irinotecan in 3 Line or More Therapy in Local Recurrence or Metastatic Breast Cancer
NCT02030678 ·Status: UNKNOWN ·Phase: PHASE2
-
An Investigational Study of BGB-58067 As a Single Agent and in Combination With Anticancer Agents in Participants With Advanced Solid Tumors
NCT06589596 ·Status: RECRUITING ·Phase: PHASE1
-
A Study of Abemaciclib (LY2835219) in Native Chinese Participants With Advanced and/or Metastatic Cancers
NCT02919696 ·Status: COMPLETED ·Phase: PHASE1
-
Phase I Study to Evaluate SIM0270 Alone or in Combination in ER+, HER2- Locally Advanced or Metastatic Breast Cancer
NCT05293964 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
A Study of H3B-6545 in Combination With Palbociclib in Women With Advanced or Metastatic Estrogen Receptor-Positive Human Epidermal Growth Factor Receptor-2 (HER2)-Negative Breast Cancer
NCT04288089 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Effects of Ribociclib and Palbociclib on Tumor and Blood Characteristics in Patients With Metastatic Breast Cancer
NCT05244434 ·Status: WITHDRAWN ·Phase: NA
-
Safety and Preliminary Effectiveness of BNT327, an Investigational Therapy for Breast Cancer, When Given in Combination With Chemotherapy
NCT06449222 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
A Study of LY3499446 in Participants With Advanced Solid Tumors With KRAS G12C Mutation
NCT04165031 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
A Study of LY2603618 in Combination With Gemcitabine in Participants With Solid Tumors
NCT01341457 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase 2 Study to Evaluate the Efficacy, Safety and Pharmacokinetics of YL202 in Patients With BC
NCT06439771 ·Status: RECRUITING ·Phase: PHASE2