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Multicenter ALS Imaging Study

NCT06735014 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 90

Last updated 2026-05-12

No results posted yet for this study

Summary

This is a multi-site study of ALS participants and healthy controls who will undergo brain and cervical spine MRIs and NfL blood testing at up-to 4 time points over the course of a year. The primary goal is to identify objective biomarkers of disease progression that are biologically relevant, linearly progressive, and sensitive to change.

Conditions

Interventions

DIAGNOSTIC_TEST

Magnetic Resonance Imaging

Participants will undergo 3T MRI scanning of the brain and cervical spine MRIs

DIAGNOSTIC_TEST

Plasma neurofilament light chain (NfL) quantification

Participants will undergo a blood draw for the quantification of plasma neurofilament light chain

Sponsors & Collaborators

  • Food and Drug Administration (FDA)

    collaborator FED

  • Minnesota Office of Higher Education

    collaborator OTHER_GOV

  • University of Minnesota

    lead OTHER

Principal Investigators

  • Pramod Pisharady, PhD · University of Minnesota

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-09-15
Primary Completion
2027-08-31
Completion
2028-08-31

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06735014 on ClinicalTrials.gov