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Whole Genome Sequencing for Blood Group Genotyping and Definition as Exemplified on U- and St(a)+.

NCT02534519 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 8

Last updated 2015-08-27

No results posted yet for this study

Summary

No health condition(s) are studied. Genetic background of blood groups is studied. U- and Stones(a)+ ("Caucasian type") are used as proof-of-principle samples. Disease associations of all blood group genes investigated are very rare, e.g. \< 1 among 1'000 Swiss individuals (see table 1), and are not to be expected in the course of this study.

Genomic DNA of 2 U- samples were both provided as blinded reference material from New York and Vienna blood centres, respectively. Both donors are lost for follow up, and although there is no documented evidence for refusal of the respective donors to use their material in research projects, samples still lack informed consent.

Conditions

  • Genetic Blood Group (bg) Polymorphism in U Negativity and St(a) of MNSs

Interventions

OTHER

Whole Genome Sequencing (WGS)

There will be no interventions needed other than blood sampling (20 mL blood) in the course of routine blood donation (450 mL blood) for 8 out of 10 individuals planned to be included as specimen, or reference samples in the study.

Sponsors & Collaborators

  • Blood Donation Service Zurich, SRC

    lead OTHER

Principal Investigators

  • Christoph Gassner, PhD · Blutspende Zürich, Dienstleistungszentrum

Eligibility

Min Age
1 Year
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-07-31
Primary Completion
2016-06-30
Completion
2018-06-30

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02534519 on ClinicalTrials.gov