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Study to Identify the Genetic Variations Associated With Phantom Limb Pain

NCT01462448 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 726

Last updated 2025-08-12

No results posted yet for this study

Summary

The purpose of this study is to determine if there is a genetic component to phantom limb pain. DNA will be analyzed for single nucleotide polymorphisms (SNPs) between the control and phantom limb pain group. Total RNA will also be isolated and profiled to asses the degree to which our gene(s) of interest are expressed in the presence or absence of phantom limb pain. Some proteins, such as inflammatory antibodies or the neurotrophin brain-derived neurotrophic factor (BDNF), will also be assessed for their association(s) with phantom limb pain.

Conditions

  • Phantom Limb

Interventions

PROCEDURE

Blood Draw

Single blood draw of 30 ml

Sponsors & Collaborators

  • Uniformed Services University of the Health Sciences

    collaborator FED

  • Henry M. Jackson Foundation for the Advancement of Military Medicine

    lead OTHER

Principal Investigators

  • Paul F. Pasquina, MD, MC · Walter Reed National Military Medical Center (WRNMMC)

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-03-31
Primary Completion
2014-04-30
Completion
2023-08-06

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01462448 on ClinicalTrials.gov