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Markers of Defective Membrane Remodelling in Scott-like Syndromes

NCT00617721 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 29

Last updated 2016-06-17

No results posted yet for this study

Summary

Purpose: Identification of the gene(s) involved in plasma membrane remodelling. Identification of the circulating markers affected by the defective membrane remodelling in a collection of families with unexplained provoked hemorrhages and evaluation of their prognosis value in the assessment of the hemostatic cellular response.Hypothesis: Scott syndrome is rare a familial disorder characterized by provoked haemorrages in homozygous-type patients due to isolated membrane remodelling deficiency. Membrane remodelling is necessary for cellular hemostatic responses.

Conditions

  • Unexplained Isolated Provoked Hemorrhages
  • Familial Bleeding Disorder
  • Scott Syndrome

Interventions

OTHER

Blood withdrawal

Observational study. Limited blood withdrawal. Any other intervention will be determined by the patient's clinical status.

Sponsors & Collaborators

  • Louis Pasteur University, Strasbourg

    collaborator OTHER

  • Institut National de la Santé Et de la Recherche Médicale, France

    collaborator OTHER_GOV

  • Aventis, Génopôle d'Evry.

    collaborator UNKNOWN

  • University Hospital, Strasbourg, France

    lead OTHER

Principal Investigators

  • Lélia GRUNEBAUM, MD · Hôpitaux Universitaires de Strasbourg

Eligibility

Min Age
2 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2008-06-30

Countries

  • France
  • Martinique

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00617721 on ClinicalTrials.gov