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Effect of Short-term Simulated Altitude Exposure on Cardiopulmonary Functional Capacity

NCT02523716 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 8

Last updated 2023-12-06

No results posted yet for this study

Summary

To determine if exposure of older volunteers, age 50-70y, who are healthy, but not physically active, to 7 days of mild hypoxia (15% oxygen, equivalent 2440m) will improve cardiopulmonary functional capacity.

Conditions

Interventions

OTHER

Hypoxia

Participants live within an altitude residence facility. Hypoxic acclimatisation will be achieved by venting the rooms with air containing a reduced oxygen content. The degree of hypoxia is ramped over a 2-day period as participants experience 14 hours of overnight hypoxic exposure (simulating altitude of : 1830m on Day 1; 2130m on Day 2). The final 5 days will be spent entirely in the altitude residence facility at a consistent hypoxia level (simulating approximately 2440m).

OTHER

Normoxia

Participants will live in the altitude residence facility. As a sham-control, normal sea level air will be circulated throughout the house.

Sponsors & Collaborators

  • University of Oxford

    collaborator OTHER

  • University of Limerick

    lead OTHER

Principal Investigators

  • Thomas Smith (Chief Investigator), MBBS, DPhil, FRCA, FAsMA · University of Oxford

  • Phillip Jakeman, BSc, MSc, PhD · University of Limerick

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
50 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-05-31
Primary Completion
2015-09-30
Completion
2015-12-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02523716 on ClinicalTrials.gov