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The Effect of Administration of Small Doses of Thyroxine on Glucose and Lipid Metabolism, in Type 2 Diabetes Mellitus.

NCT02509858 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 33

Last updated 2015-07-28

No results posted yet for this study

Summary

We investigated the effect of the administration of small doses of thyroxine to healthy humans and patients with type 2 diabetes on postprandial forearm muscle glucose uptake, insulin sensitivity indices, lipid metabolism, in vitro glucose uptake and GLUT4 recruitment in the plasma membrane of monocytes.

Conditions

Interventions

DRUG

thyroxine

treatment with 50μg of thyroxine once daily for two months.

DRUG

Placebo

treatment with 50μg of placebo, once daily, for two months.

OTHER

A meal (730kcal, 50%carbohydrate, of which 38% was starch, 40% fat, and 10% protein)

Sponsors & Collaborators

  • Attikon Hospital

    lead OTHER

Principal Investigators

  • GEORGE DIMITRIADIS, MD, Phd · 2nd Department of Internal Medicine, Research Institute and Diabetes Center, Athens University Medical School, Attikon Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2009-02-28
Primary Completion
2014-02-28
Completion
2015-07-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02509858 on ClinicalTrials.gov