MedTrace Logo

The Role of Arachidonic Acid Metabolites, From Patients With Metabolic Syndrome

NCT02498119 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 12

Last updated 2016-06-21

No results posted yet for this study

Summary

The purpose of this study is to determine whether an increase in lipid bodies in leukocytes will lead to an increase in eicosanoid production. The 2nd purpose is to determine if there is a significant correlation between lipid body formation and enhanced generation of both Lipoxygenase (LO) and COX derived eicosanoids. The 3rd purpose is, if lipid bodies are involved in arachidonic acid (AA) metabolism, then AA present in these lipid rich structure must be released by phospholipases and the free Arachidonic Acid (AA) must have access to the eicosanoid forming enzyme. The fourth objective is to determine the compartmentalisation of cPLA2 and MAP kinases including ERK1, ERK2, p85 and p38 are involved in AA liberation within lipid bodies.

Conditions

Sponsors & Collaborators

  • University of Malaya

    lead OTHER

Principal Investigators

  • Gracie Ong Siok Yan · Senior Consultant

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-11-30
Primary Completion
2016-01-31
Completion
2016-09-30

Countries

  • Malaysia

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02498119 on ClinicalTrials.gov