The Effect of Dietary Fat Modification on Risk Factors Associated With the Metabolic Syndrome

Summary

The LIPGENE Human Dietary Intervention Study, multi-centre, trans -European, single-blinded, randomised, controlled trial with two principal aims. Firstly to determine the relative efficacy of reducing dietary SFA consumption, by altering quality of dietary fat and reducing the quantity of dietary fat, on metabolic and molecular risk factors of the metabolic syndrome. Secondly to determine if common genetic polymorphisms affect an individual's responsiveness to dietary therapy.

Conditions

• Metabolic Syndrome

Interventions

BEHAVIORAL

Dietary Fatty Acid Modification

Sponsors & Collaborators

• University of Reading

  collaborator OTHER

• University of Oslo

  collaborator OTHER

• Institut National de la Santé Et de la Recherche Médicale, France

  collaborator OTHER_GOV

• Maastricht University Medical Center

  collaborator OTHER

• Universidad Nacional de Córdoba

  collaborator OTHER

• Jagiellonian University

  collaborator OTHER

• Uppsala University

  collaborator OTHER

• University College Dublin

  lead OTHER

Principal Investigators

• Helen M Roche, PhD · University of Dublin, Trinity College

• Christine Williams, PhD · University of Reading

• Christian Drevon, MD · University of Oslo

• Denis Larion, PhD · INSERM, Marseille

• Wim Saris, PhD · Maastricht University

• Jose Lopez Miranda, MD, PhD · Universidad de Córdoba

• Aldona Dembinska-Kiec, MD · The Jagiellonian University Medical College

• Bengt Vessby, MD · Uppsala University

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

SINGLE_GROUP

Eligibility

Min Age

35 Years

Max Age

70 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2004-02-29

Completion

2007-01-31

Countries

• Ireland

Study Locations