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Chikungunya Arthritis in the Americas

NCT02463968 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2017-06-27

No results posted yet for this study

Summary

Chikungunya is a mosquito-borne viral illness that leads to chronic joint pain in approximately one half of patients. The mechanisms leading to long term arthritis in humans has not been well established. There is some evidence from animal studies that activated macrophages with persistent viral infection may play a role in chronic arthritis however these mechanisms have not yet been identified in humans. It is hypothesized that activated macrophages harboring persistent active chikungunya virus are responsible for chronic arthritis and joint pain in patients. The focus of this proposal is to evaluate synovial fluid and blood for direct viral persistence and activated macrophages that may clarify the mechanism of inflammatory injury. The results of this study will be directly applicable to tailoring trials of therapeutics.

Conditions

Interventions

PROCEDURE

Venipuncture for blood draw

Samples will include blood. Blood samples will be collected via venipuncture.This is a part of standard of care of new new onset joint effusion and is not a novel intervention.

PROCEDURE

Arthrocentesis for synovial fluid draw

Samples will include joint fluid analysis in participants with a knee effusion. Synovial fluid will be drawn via arthrocentesis under sterile conditions. This is a part of standard of care of new new onset joint effusion and is not a novel intervention.

Sponsors & Collaborators

  • Global Disease Research

    collaborator UNKNOWN

  • US Army Medical Research Institute of Infectious Diseases

    collaborator FED

  • Broad Institute of MIT and Harvard

    collaborator OTHER

  • Allied Research Society

    collaborator UNKNOWN

  • George Washington University

    lead OTHER

Principal Investigators

  • Aileen Y Chang, MD MSPH · George Washington University

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-08-27
Primary Completion
2017-06-30
Completion
2017-06-30

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02463968 on ClinicalTrials.gov