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Anticholinergic Premedication Induced Fever in Pediatric Ambulatory Anesthesia With Ketamine

NCT02430272 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 84

Last updated 2015-05-01

No results posted yet for this study

Summary

Anticholinergic drugs have traditionally been used for their antisialagogue properties. But use of anticholinergic drugs can interfere with thermoregulation via inhibition of the parasympathetically mediated sweat secretion. Sweating inhibition can reduce heat elimination, and children's thermoregulation depend more on sweating than adults and they can become hyperthermic when given these agents.

The investigators evaluated the fever-causing effects of adjunctive anticholinergics in children under general anesthesia using ketamine.

Conditions

Interventions

DRUG

Glycopyrrolate

Intravenously administered 0.005mg/Kg of glycopyrrolate in intervention group

Sponsors & Collaborators

  • Inje University

    lead OTHER

Principal Investigators

  • Won Joo Choe, M.D. Ph.D · Inje Univ.

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
12 Months
Max Age
8 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-05-31
Primary Completion
2014-11-30
Completion
2014-12-31

Countries

  • South Korea

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02430272 on ClinicalTrials.gov