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Does Ketamine Attenuate Depression of Respiratory and Cardiac Functions

NCT01501786 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 150

Last updated 2013-07-30

No results posted yet for this study

Summary

Normal cardiac and respiratory functions should be maintained during pediatric cardiac catheterization. Propofol has become a popular choice for sedation in children, however, it depresses cardiac and respiratory functions. Some investigators reported that ketamine attenuates its depressant effect, but it remains unclear whether ketamine reduces cardiac and respiratory depression caused by propofol in pediatric cardiac catheterization.

Conditions

  • Congenital Heart Disease
  • Sedated for Cardiac Catheterization

Interventions

DRUG

control

propofol 8mg/kg/h saline 0.24 ml/kg/h

DRUG

Ket10

propofol 6.4 mg/kg/h ketamine 10 microg/kg/min

DRUG

Ket20

propofol 4.8 mg/kg/h ketamine 20 microg/kg/min

Sponsors & Collaborators

  • Ibaraki Children's Hospital

    lead OTHER

Principal Investigators

  • Kazuhiko Okuyama, MD · Ibaraki Children's Hospital

  • Yuki Takeda, MD · Ibaraki Children's Hospital

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
6 Months
Max Age
10 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-01-31
Primary Completion
2013-05-31
Completion
2013-05-31

Countries

  • Japan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01501786 on ClinicalTrials.gov