Effect of Dexmedetomidine After Thyroidectomy

Summary

The purpose of the present study was to compare the effect of dexmedetomidine which is administered during emergence in adult patients undergoing elective thyroidectomy on smooth emergence form general anesthesia (reducing agitation or coughing, signs of hypertension or tachycardia, or etc.) and postoperative outcome (postoperative bleeding and hospital staying).

Conditions

• Thyroid Tumor

Interventions

DRUG

Desflurane

Anesthesia is maintained with desflurane

DRUG

Remifentanil

Remifentanil is infused for the maintenance of anesthesia during surgery and discontinued 15 min before end of surgery

PROCEDURE

Thyroidectomy

The aim of this study is evaluation of effect of dexmedetomidine on emergence response and postoperative outcome after thyroidectomy

OTHER

Vital signs

Systolic blood pressure, diastolic blood pressure, mean arterial pressure, and heart rate are measured before infusion of testing drugs, after infusion of them (5 min, 10 min, and 15 min), during extubation (0 min and 5 min after extubation), and at recovery room. And the complications such as hypotension, hypertension, bradycardia, tachycardia, and desaturation after infusion of testing drugs are observed.

BEHAVIORAL

Cough reflex

During recovery from anesthesia at operation room, cough reflex is measured and rated. \[Grade 0, no cough; Grade 1, single cough with mild severity; Grade 2, cough persistence less than 5 s with moderate severity; Grade 3, severe, persistent cough for more than 5 s (bucking)\]

BEHAVIORAL

Ramsay Sedation Scale

When the patient has fully awaken and transferred to the recovery room, Ramsay Sedation Scale is measured. 1. Awake Patient anxious and agitated or restless or both! 2. Patient cooperative, oriented and tranquil! 3. Patient responds to commands only! 4. Asleep A brisk response to a light glabellar tap or loud auditory stimulus! 5. A sluggish response to a light glabellar tap or loud auditory stimulus! 6. No response to a light glabellar tap or loud auditory stimulus

OTHER

Extubation time and Recovery time

The time from discontinuing anesthetic gas to endotracheal extubation is measured. And the time from the discontinuing of anesthetic gas to transferring to the recovery room is also measured.

BEHAVIORAL

Visual analogue scale

The severity of pain after surgery is measured by VAS (at recovery room, POD 1, POD 2, and POD 3)

OTHER

Postoperative bleeding

The amount of postoperative bleeding which is collected in the barovac is measured.

OTHER

Postoperative complications

Postoperative complications after thyroidectomy such as hoarseness and hematoma, and reoperation due to such complication is observed.

OTHER

Time to remove drainage and duration of hospital staying

The time from the end of surgery to remove drainage is measured. And the duration of hospital staying is measured.

DRUG

Dexmedetomidine

Dexmedetomidine has started infusion for 15 min (rate of 0.6 ug/kg/hr) before end of surgery as experimental intervention

DRUG

Normal saline

Normal saline has started infusion for 15 min (as same rate of dexmedetomidine) before end of surgery as control intervention

Sponsors & Collaborators

• Chosun University Hospital

  lead OTHER

Principal Investigators

• Ki Tae Jung, M.D. · Chosun University Hospital

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Model

PARALLEL

Eligibility

Min Age

20 Years

Max Age

60 Years

Sex

FEMALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2014-04-30

Primary Completion

2020-11-21

Completion

2020-11-25

Countries

• South Korea

Study Locations