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Collaborative Care for the Detection and Management of Depression Among Adults Receiving Antiretroviral Therapy in South Africa

NCT02407691 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 2002

Last updated 2023-11-29

No results posted yet for this study

Summary

With increasing access to antiretroviral therapy (ART) in South Africa, HIV has transitioned from a terminal illness to a long-term condition. It is likely to be accompanied by higher levels of disability and other chronic non-communicable diseases, resulting from the HIV itself, as well as adverse effects of medication. This requires an expansion of the purview of HIV care beyond direct HIV clinical care to also include a more comprehensive and integrated package of treatment and care for physical and mental conditions and their consequences. COBALT is a pragmatic cluster randomized controlled trial (RCT) in public sector primary care clinics in the North West Province of SA. It will assess mental health and HIV outcomes for depressed adults receiving ART by measuring the real-world effectiveness of a facility-based stepped care intervention combining depression case detection by non-physician clinicians with group counselling intervention delivered by lay-health workers.

Conditions

Interventions

OTHER

Primary care 101 plus mental health

A facility-based stepped care intervention combining depression case detection by non-physician clinicians with group counselling intervention delivered by lay-health workers.

OTHER

Standard Primary Care 101

Standard Primary Care 101 guideline with standard training

Sponsors & Collaborators

  • King's College London

    collaborator OTHER

  • University of KwaZulu

    collaborator OTHER

  • University of Cape Town

    lead OTHER

Principal Investigators

  • Lara Fairall, PhD · University of Cape Town, Cape Town, South Africa

  • Inge Pitersen, PhD · University of KwaZulu-Natal, Durban, South Africa

  • Graham Thornicroft, PhD · King's College London

Study Design

Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-04-30
Primary Completion
2018-01-31
Completion
2018-01-31

Countries

  • South Africa

Study Locations

More Related Trials

Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02407691 on ClinicalTrials.gov