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Effect of Sevoflurane, Propofol and Dexmedetomidine on Delirium & Neuroinflammation in Mechanically Ventilated Patients

NCT02394418 · Status: WITHDRAWN · Phase: PHASE4 · Type: INTERVENTIONAL

Last updated 2019-08-15

No results posted yet for this study

Summary

Assessment of sedative effects of sevoflurane, dexmedetomidine and propofol on the clinical course of delirium, SIRS and neuroinflammation in mechanically ventilated patients using CAM-ICU scale, GSK-3beta and protein S100b in serum.

Conditions

  • Delirium

Interventions

DRUG

Sevoflurane

Treatment of delirium by inhaled sevoflurane

DRUG

Propofol

Treatment of delirium by propofol i.v. infusion

DRUG

Dexmedetomidine

Treatment of delirium by dexmedetomidine i.v. infusion

Sponsors & Collaborators

  • Moscow Regional Research and Clinical Institute (MONIKI)

    lead OTHER_GOV

Principal Investigators

  • Valery Likhvantsev, MD,PhD · Moscow Regional Research Clinical Institute

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-09-01
Primary Completion
2018-05-31
Completion
2018-08-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02394418 on ClinicalTrials.gov