Aspirin for Venous Ulcers: Randomised Trial (AVURT)

Summary

This efficacy study evaluates the safety and effectiveness of aspirin for venous leg ulcer healing. The study also examines whether patients can be recruited to a larger study. Patients with chronic venous leg ulceration presenting and undergoing care in leg ulcer community clinics or hospital out-patient clinics, or registered with a clinic but are receiving care at home will be recruited. All patients will receive standard compression bandaging. Half of the participants will be randomised to receive aspirin, while the other half will receive a placebo.

Conditions

• Venous Leg Ulcer

Interventions

DRUG

Aspirin

Each 300mg aspirin capsule will contain over-encapsulated 4 x Aspirin 75mg tablets.

DRUG

Placebo (for Aspirin)

Each placebo capsule will contain a lactose and magnesium stearate blend, and will appear identical in weight, colour and size to the matched aspirin capsules.

Sponsors & Collaborators

• University of York

  collaborator OTHER

• University of Manchester

  collaborator OTHER

• Bradford Teaching Hospitals NHS Foundation Trust

  collaborator OTHER_GOV

• Harrogate & District NHS Foundation Trust

  collaborator OTHER

• Hull University Teaching Hospitals NHS Trust

  collaborator OTHER_GOV

• University of Nottingham

  collaborator OTHER

• Cardiff University

  collaborator OTHER

• University of Newcastle Upon-Tyne

  collaborator OTHER

• St George's, University of London

  lead OTHER

Principal Investigators

• Robert J Hinchliffe, MD, FRCS · St George's Healthcare NHS Trust

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2015-07-10

Primary Completion

2016-08-18

Completion

2016-11-11

Countries

• United Kingdom

Study Locations