Also known as: St. Jude
St. Jude Children’s Research Hospital experts are creating evidence-informed consensus guidelines covering brain tumor diagnosis, pharmacogenomics, survivorship care, and rare blood disorders. Their work helps clinicians translate the latest data into improved diagnosis, treatment, and follow-up care globally.
Only 17.7% of pediatric anticancer drugs advance to phase 3 trials, and just 12% earn FDA approval within 10 years, compared to 38.7% for adult drugs. The pace of pediatric approvals has accelerated recently, but funding and market size constraints remain.
St. Jude researchers linked specific childhood cancer therapies to DNA fingerprints in second neoplasms, potentially improving survivor surveillance and guiding safer treatments. Separately, the Global Platform for Access to Childhood Cancer Medicines has helped Nepal and Ghana build national cancer registries and implement national strategies.
WHO in January 2024 launched its first list of priority childhood cancer drug formulations, naming six medicines that still lack optimal child-friendly versions. The agency says about 400,000 children and adolescents develop cancer each year and is working to expand access to safe, effective paediatric formulations.
New AI-powered platforms enable same-day cancer treatment decisions and streamline clinical trial matching. University of Utah's μPharma chip predicts drug responses in under four hours, while City of Hope's HopeLLM system matches patients to trials across its national network.
New research examines both the long-term biological aging effects of childhood cancer treatments and proposes alternative treatment sequencing strategies to prevent tumor resistance and improve cure rates.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07719972 |
Universal Newborn Screening For Sickle Cell Disease In Mozambique |
NOT_YET_RECRUITING | NA |
| NCT07701694 |
Functional Evaluation in Patients With Urea Cycle Disorders (UCD) During a Driving Task |
RECRUITING | |
| NCT07675083 |
Bereaved Parent Conversations on Hope |
RECRUITING | NA |
| NCT07663539 |
Insights From Bereaved Parents and Oncologists |
RECRUITING | |
| NCT07616154 |
Haploidentical Donor Hematopoietic Cell Transplant for Sickle Cell Disease |
RECRUITING | PHASE2 |
| NCT07594392 |
Clinical Assessment and Targeted Imaging to Characterize High-Risk Atherosclerotic Cardiovascular Disease of Survivors in SJLIFE |
NOT_YET_RECRUITING | |
| NCT07585136 |
Stem Cell Mobilization and Apheresis for Life-threatening Blood Disorders |
NOT_YET_RECRUITING | PHASE1 |
| NCT07531498 |
Muscle Aging Phenotypes in Childhood Cancer Survivors |
NOT_YET_RECRUITING | |
| NCT07516301 |
Feasibility of Incorporating a Standardized Substance Use Measure With Linked-Brief Intervention Into Routine Psychosocial Care of Adult Childhood Cancer Survivors |
RECRUITING | NA |
| NCT07514819 |
Integration of Adaptive Proton Therapy in Pediatric Solid Tumors and Hodgkin's Lymphoma |
RECRUITING | NA |
