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Metformin to Augment Strength Training Effective Response in Seniors (MASTERS)

NCT02308228 · Status: COMPLETED · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 109

Last updated 2019-09-17

Study results available
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Summary

The purpose of this study is to determine whether a commonly prescribed drug, metformin, can enhance the benefits seen during resistance exercise such as increased muscle mass and strength.

Conditions

  • Aging

Interventions

BEHAVIORAL

Progressive Resistance Training

Participants will complete 14 weeks (42 sessions, 3x/week) of progressive resistance training which will consist of 8 constant load movements to train all major muscle groups bilaterally.

DRUG

Metformin

Participants will be randomized to receive metformin in conjunction with their strength training program.

Sponsors & Collaborators

  • University of Alabama at Birmingham

    collaborator OTHER

  • Philip Kern

    lead OTHER

Principal Investigators

  • Charlotte Peterson, Ph.D. · University of Kentucky

  • Philip Kern, M.D. · University of Kentucky

  • Marcas Bamman, Ph.D · University of Alabama at Birmingham

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-01-14
Primary Completion
2017-12-14
Completion
2018-06-28
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02308228 on ClinicalTrials.gov