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Changes of Oropharyngeal Flora

NCT02303301 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 145

Last updated 2020-10-08

No results posted yet for this study

Summary

Hospitalised patients have in contrast to healthy people enteric pathogenic bacteria in their oropharynx Increased risk of pneumonia due to the pathogens in the oropharynx Probiotics can reduce such bacteria in intubated critically ill patients This study will use two strain of probiotic bacteria for half of the patients and a placebo for the rest Active arm gurgles with a suspension twice a day Cultures at inclusion and at set time intervals The results of cultures from the two groups will be compared as will the use of antibiotics

Conditions

  • Pharyngeal Bacterial Colonization
  • Pneumonia

Interventions

DIETARY_SUPPLEMENT

Probiotics

Cultures from the oropharynx

DIETARY_SUPPLEMENT

Placebo

Cultures from the oropharynx

Sponsors & Collaborators

  • Probi AB

    collaborator INDUSTRY

  • Region Skane

    lead OTHER

Principal Investigators

  • Bengt Klarin, MD, PhD · Lund University Hospital

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-10-31
Primary Completion
2019-03-31
Completion
2020-07-31

Countries

  • Sweden

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02303301 on ClinicalTrials.gov