MedTrace Logo

Probiotics Against Pathogenic Bacteria in Connection With Anaesthesia

NCT01521650 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 42

Last updated 2021-03-10

No results posted yet for this study

Summary

Longer surgical procedures require intubation and there is a potential risk of contaminating the lower airways with pathogenic bacteria from the mouth and oropharynx.

Healthy people seldom have pathogenic bacteria originating from the gastro-intestinal canal but those do occur among patients, both in those not so sick and patients with more severe problems.

For ICU patients we have seen a reduction of emerging enteric bacteria in patients given oral care with probiotics and this is a pilot study to explore the possibility of the same kind of positive effects in patients due for longer (more than 4 hours of anesthesia) procedures.

Randomisation

* No prophylaxis
* Preparation with a probiotic suspension before intubation.

Cultures

* oropharynx

* before treatment
* after intubation
* before extubation
* day 1 postoperatively
* tracheal secretions

* after intubation
* before extubation

Conditions

  • Oropharyngeal Microbiology

Interventions

DIETARY_SUPPLEMENT

Probiotics

Patients will gurgle and swallow a mixture of probiotic bacteria

Sponsors & Collaborators

  • Lund University

    collaborator OTHER

  • Region Skane

    lead OTHER

Principal Investigators

  • Bengt klarin, MD PhD · Lund University

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-01-31
Primary Completion
2019-03-31
Completion
2020-07-31

Countries

  • Sweden

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01521650 on ClinicalTrials.gov