Low Load, High-repetitive Elastic Band Resistance Training in COPD

Summary

Recent work have shown that low load, high-repetitive single limb resistance training, if compared to a control, can increase limb muscle function and functional exercise capacity in patients with chronic obstructive pulmonary disease (COPD) while avoiding the occurrence of limiting exertional symptoms. However, no comparison to another exercise regimen have been performed. In addition neither the intramuscular nor the mechanism of this exercise regimen have been investigated and represents the aim of the proposed project. We will in a prospective, assessor-blind; block randomized controlled, parallel-group trial compare single-limb to two-limb low load, high-repetitive resistance training in patients with severe and very severe COPD

The research hypothesizes are:

* that single-limb low-load high-repetitive resistance training will provide larger gain in the 6-min walking distance than two-limb low-load high- repetitive resistance training in patients with severe to very severe (stage III-IV) COPD.
* that eight weeks of single limb training should also be associated with larger physiological (increased muscle endurance, less muscle fatigue and deoxygenation) and structural (muscle protein synthesis, fiber-type distribution and capillarization) muscle adaptations to training, lower cardio- respiratory demand, as well a greater increase in health-related quality of life in comparison to two-limbs simultaneous training.

We will also compare the groups at baseline to investigate the acute effects and mechanisms of single-limb to two-limb low load, high-repetitive resistance training, a comparison that also will include healthy matched controls.

The research hypothesizes are:

* that involving a large muscle mass during exercise (e.g., two-limb low load, high-repetition resistance training) compared to involving a small muscle mass during training (e.g., single limb low load, high-repetition resistance training) would lead to larger restraints on the cardiorespiratory system in patients with severe to very severe COPD. Conversely, single limb interventions should produce less dyspnea and more muscle deoxygenation and fatigue than two-limb simultaneous exercise while healthy controls will be able to perform both legs/arms exercise without a central constraint, and no negative consequences on muscle fatigue or exercise stimulus.

Conditions

• Pulmonary Disease, Chronic Obstructive
• Healthy

Interventions

OTHER

Single limb

Low load, high-repetitive resistance training. * single limb at a time (e.g., one arm or one leg) * elastic bands * 8 weeks * 3 times/week, * each session 60 minutes * seven resistance exercises: Latissimus row, leg curl, elbow flexion, chestpress, plantar flexion, shoulder flexion and knee extension * maximal number of repetitions (RM) \* 3 sets in each exercise.

OTHER

Two limb

Low load, high-repetitive resistance training. * two limbs at a time (e.g., both arms or both legs) * elastic bands * 8 weeks * 3 times/week, * each session 60 minutes * seven resistance exercises: Latissimus row, leg curl, elbow flexion, chestpress, plantar flexion, shoulder flexion and knee extension * maximal number of repetitions (RM) \* 3 sets in each exercise.

Sponsors & Collaborators

• Saey, Didier, M.D.

  collaborator INDIV

• Maltais, Francois, M.D.

  collaborator INDUSTRY

• Laval University

  lead OTHER

Principal Investigators

• Francois Maltais, MD · Institut universitaire de cardiologie et de pneumologie de Québec (IUCPQ)

• Didier Saey, Pht, PhD · Institut universitaire de cardiologie et de pneumologie de Québec (IUCPQ)

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

40 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2014-11-30

Primary Completion

2017-02-28

Completion

2017-02-28

Countries

• Canada

Study Locations