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Effect of Probiotic Inersan and Doxycycline in Chronic Periodontitis

NCT02174757 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2014-12-15

No results posted yet for this study

Summary

Periodontitis is a multifactorial disease that can lead to the destruction of supporting tissues of the teeth resulting in pocket formation, recession or both. Since the primary etiological factors for periodontal disease are bacteria in supra and sub gingival biofilm, efforts for disease prevention and treatment are mainly focused on pathogen reduction and strengthening of epithelial barrier, thus contributing to decreased susceptibility to infection. Due to emergence of antibiotic resistance and frequent recolonization of treated sites with pathogenic bacteria, there was need for a new treatment paradigm to be introduced to periodontal disease. The need was fulfilled by the introduction of Probiotics and Bacterial Replacement Therapy. The term probiotic is derived from the Greek, meaning "for life" are microorganisms proven to exert health promoting influences in humans and animals. Food and Agriculture Organization and WHO have stated that there is potential for probiotic foods to provide health benefits and that specific strains are safe for human use.

Conditions

  • Chronic Periodontitis

Interventions

DRUG

Inersan

Probiotic

DRUG

Doxycycline

Antibiotic

Sponsors & Collaborators

  • Sree Mookambika Institute of Dental Sciences

    collaborator UNKNOWN

  • CD Pharma India Pvt. Ltd.

    lead INDUSTRY

Principal Investigators

  • Arya K.S., BDS · Sree Mookambika Institute of Dental Sciences

  • Elizabeth Koshi, MDS · Sree Mookambika Institute of Dental Sciences

  • Arun Sadasivan, MDS · Sree Mookambika Institute of Dental Sciences

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
25 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-08-31
Primary Completion
2014-11-30
Completion
2014-11-30

Countries

  • India

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02174757 on ClinicalTrials.gov