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Effect of Pre-injection of Lidocaine on Myoclonus Induced by Induction With Etomidate in Elderly Patients During General Anesthesia

NCT02141737 · Status: UNKNOWN · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 272

Last updated 2014-05-19

No results posted yet for this study

Summary

To evaluate the effect of pre-injection of lidocaine on myoclonus induced by induction with etomidate during general anesthesia in elderly patients

Conditions

  • General Anesthesia

Interventions

DRUG

Lidocaine Hydrochloride Injection

Lidocaine injection should be give before the injection of etomidate. In groups L1 and L2, 20 mg and 30 mg lidocaine injection will be diluted to 2ml separately.

DRUG

Etomidate Fat Emulsion Injection

1 minute after the injection of lidocaine, 0.3 mg/kg etomidate will be given in 30 to 60 s.

DRUG

normal saline

2 ml normal saline will be given 1 minute before the injection of etomidate in patients in group C, and in group L1 and L2, normal saline is used to dilute lidocaine injection to 2 ml.

DRUG

Midazolam Injection

0.02 mg/kg midazolam will be given to the patients in all groups 90 s after the injection of etomidate.

DRUG

Fentanyl Citrate Injection

3 μg/kg fentanyl will be given to patients in all groups after the injection of midazolam.

DRUG

Rocuronium Injection

0.6 mg/kg rocuronium will be given to patients in all groups after the injection of fentanyl.

Sponsors & Collaborators

  • Tang-Du Hospital

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
60 Years
Max Age
81 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-05-31
Primary Completion
2014-10-31
Completion
2014-10-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02141737 on ClinicalTrials.gov