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The Effect of Deep Neuromuscular Blockade on Requirement of Intravenous Anesthetic Agent

NCT03890406 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 88

Last updated 2020-06-30

No results posted yet for this study

Summary

Recently, deep neuromuscular blockade during general anesthesia has been studied by many authors regarding various effects upon patients' outcomes and surgical conditions. We believe deep neuromuscular blockade can be especially beneficial in laparoscopic surgery, because it can expand surgical space and prevent patients' minute movements that can disturb precise operations. In clinical situations, anesthetists tend to compensate the insufficiency of neuromuscular blockade by increasing the dose of other anesthetic agents, which can prolong patients' recovery time and impair the surgical condition. In this study, we plan to divide the patients into 2 groups according to the depth of neuromuscular blockade, and compare the dose of anesthetic agent used to maintain surgical condition.

Conditions

  • Laparoscopy
  • General Anesthesia
  • Neuromuscular Blockade

Interventions

DRUG

Rocuronium: PTC(Post-tetanic count) 1~2

Deep neuromuscular blockade will be maintained using continuous infusion of rocuronium.

DRUG

Rocuronium: TOF(Train-of-four) 1~2

Moderate neuromuscular blockade will be maintained using continuous infusion of rocuronium.

Sponsors & Collaborators

  • Seoul National University Bundang Hospital

    lead OTHER

Principal Investigators

  • Ah Young Oh, MD, PhD · Seoul National University Bundang Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-04-01
Primary Completion
2019-12-31
Completion
2020-03-31

Countries

  • South Korea

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03890406 on ClinicalTrials.gov