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EEG & Behavioral Predictors of Changes in Smoking Trajectories in Young Light Smokers

NCT02129387 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 115

Last updated 2022-11-01

No results posted yet for this study

Summary

The purpose of the proposal is to identify new predictors of smoking progression in young light smokers (YLS: 18-25 years \& cpd \< 5) using an 18-month longitudinal design and to relate these predictors of progression to the genetic profile most highly associated with smoking progression. A number of novel predictors will be assessed in 128 YLS. Predictors will include individual differences (IDs) in EEG, reward sensitivity, attentional performance, and mood during abstinence and in response to standardized and to self-selected acute nicotine doses (ANIC), as well as genetically influenced affective traits, and smoking history. The associations of a compelling genetic functional variant polymorphism, rs16969968, in the alpha5 nicotinic receptor subunit will also be related to smoking progression and the novel predictors. The study is expected to provide insights into IDs in mechanisms and predictors that contribute to smoking trajectories in YLS and thereby lead to targeted pharmacotherapy and behavioral interventions for at-risk YLS.

Conditions

  • Nicotine Dependence

Sponsors & Collaborators

  • Southern Illinois University Carbondale

    lead OTHER

Principal Investigators

  • David G Gilbert, PhD · Southern Illinois University Carbondale

Eligibility

Min Age
18 Years
Max Age
25 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-04-30
Primary Completion
2021-10-31
Completion
2021-11-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02129387 on ClinicalTrials.gov