Infective Endocarditis in Developing Countries, a Prospective, Observational, Multicentre Study

Summary

Introduction. Comprehensive data on infective endocarditis in developing countries are scarce.

Objectives: Description of the characteristics (clinical and microbiological) and assessment of the outcomes of infective endocarditis in low-income countries.

Methods : Prospective, Observational, Multicentre study. Inclusion criteria: patients aged over 1 year fulfilling the modified Duke criteria for infective endocarditis.

Exclusion criteria: patient included during a previous infective endocarditis episode.

Outcomes measures: Mortality at 6 months follow-up; mortality at 1 month follow-up; access to antibiotic treatment (modalities and duration), hospital length of stay and reason for discharge, and cardiac surgery when indicated.

Duration: One year (June 2014- June 2015)

Conditions

• Infective Endocarditis

Sponsors & Collaborators

• War Memorial Hospital

  collaborator OTHER

• Centers for Disease Control and Prevention

  collaborator FED

• Oxford University Hospitals NHS Trust

  collaborator OTHER

• St. Elizabeth Catholic General Hospital Shisong, Cameroun

  collaborator UNKNOWN

• CHU de Brazzaville, Congo Brazzaville

  collaborator UNKNOWN

• Polyclinique International de Bamako, Mali

  collaborator UNKNOWN

• CHR de Saint-Louis Lt Colonel Mamadou Diouf, Sénégal

  collaborator UNKNOWN

• Hôpital Général de Grand Yoff de Dakar, Sénégal

  collaborator UNKNOWN

• Bafoussam Regional Hospital, Cameroon

  collaborator UNKNOWN

• Hospital Laquinitinie de Douala

  collaborator UNKNOWN

• Yaounde Central Hospital

  collaborator OTHER_GOV

• National Hospital of Niamey

  collaborator OTHER

• Centre National Hospitalier Universitaire de Pneumo-Phtisiologie de Cotonou, Benin

  collaborator UNKNOWN

• Hospital General De Douala

  collaborator OTHER

• Eduardo Mondlane University

  collaborator OTHER

• Laos Oxford Mahosot Wellcome Research Unit

  collaborator UNKNOWN

• Mulago Hospital, Uganda

  collaborator OTHER

• Fann Hospital, Senegal

  collaborator UNKNOWN

• Institute of Cardiology Abidjan

  collaborator UNKNOWN

• Institut National de la Santé Et de la Recherche Médicale, France

  lead OTHER_GOV

Eligibility

Min Age

1 Year

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2012-04-30

Primary Completion

2015-04-30

Completion

2015-10-31

Countries

• Fiji
• Laos
• Mozambique
• Senegal
• Uganda

Study Locations