Genetic Determinants of Kawasaki Disease

Summary

Kawasaki disease (KD) is an acute self-limited vasculitis of infancy and early childhood. Most patients recover without sequelae although the inflammatory process causes permanent damage to the coronary arteries in 20-25% of untreated children. An infectious aetiology is suspected, but the causative agent has not been identified. The investigators aim to identify the genes underlying both susceptibility to Kawasaki disease, and the development of coronary artery aneurysms.

Conditions

• Kawasaki Disease
• Atypical Kawasaki Disease

Sponsors & Collaborators

• Guy's and St Thomas' NHS Foundation Trust

  collaborator OTHER

• University Hospitals Bristol and Weston NHS Foundation Trust

  collaborator OTHER

• Great Ormond Street Hospital for Children NHS Foundation Trust

  collaborator OTHER

• UK Kawasaki Support Group

  collaborator UNKNOWN

• Imperial College Healthcare NHS Trust

  collaborator OTHER

• University Hospitals of North Midlands NHS Trust

  collaborator OTHER

• Burton Hospitals NHS Foundation Trust

  collaborator OTHER

• York Teaching Hospitals NHS Foundation Trust

  collaborator OTHER

• Shrewsbury and Telford Hospitals NHS Trust

  collaborator OTHER

• East Suffolk and North Essex NHS Foundation Trust

  collaborator OTHER

• New Cross Hospital

  collaborator OTHER

• Darlington Memorial Hospital

  collaborator UNKNOWN

• Torbay Hospital

  collaborator UNKNOWN

• Peterborough City Hospital

  collaborator UNKNOWN

• University Hospitals Coventry and Warwickshire NHS Trust

  collaborator OTHER

• University Hospital of North Tees

  collaborator UNKNOWN

• Cambridge University Hospitals NHS Foundation Trust

  collaborator OTHER

• Royal Cornwall Hospitals Trust

  collaborator OTHER

• Birmingham Children's Hospital

  collaborator OTHER

• University Hospital Birmingham NHS Foundation Trust

  collaborator OTHER

• Wye Valley NHS Trust

  collaborator OTHER_GOV

• South Tees Hospitals NHS Foundation Trust

  collaborator OTHER

• Leeds General Infirmary

  collaborator UNKNOWN

• Bradford Royal Infirmary

  collaborator OTHER

• University Hospitals of Morecambe Bay NHS Trust

  collaborator OTHER

• Calderdale and Huddersfield NHS Foundation Trust

  collaborator OTHER

• St. Richard's Hospital

  collaborator OTHER

• Pinderfields General Hospital

  collaborator UNKNOWN

• Worthing Hospital

  collaborator UNKNOWN

• Airedale General Hospital

  collaborator UNKNOWN

• Sheffield Children's NHS Foundation Trust

  collaborator OTHER

• Northwick Park Hospital

  collaborator OTHER

• West Middlesex Hospital

  collaborator UNKNOWN

• Royal Albert Edward Infirmary

  collaborator UNKNOWN

• Macclesfield District General Hospital

  collaborator UNKNOWN

• Royal Oldham Hospital

  collaborator UNKNOWN

• Stepping Hill Hospital

  collaborator UNKNOWN

• North Manchester General Hospital

  collaborator UNKNOWN

• Royal Bolton Hospital NHS Foundation Trust

  collaborator OTHER

• Kingston Hospital NHS Trust

  collaborator OTHER

• Tameside Hospital NHS Foundation Trust

  collaborator OTHER

• East Surrey Hospital

  collaborator UNKNOWN

• St. George's Hospital, London

  collaborator OTHER

• Royal Alexandra Children's Hospital

  collaborator OTHER

• Imperial College London

  lead OTHER

Principal Investigators

• Professor M Levin · Imperial College London

Eligibility

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2013-02-25

Primary Completion

2022-12-30

Completion

2022-12-30

Countries

• United Kingdom

Study Locations