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Neural Substrates of Approach-Avoidance Conflict

NCT02119624 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 62

Last updated 2021-01-26

No results posted yet for this study

Summary

Background:

\- People who are dependent on alcohol drink even when they know something bad might happen. Researchers want to learn more about why they do this.

Objectives:

\- To study brain response when a person plays a game in different threat conditions.

Eligibility:

* Healthy right-handed adult heavy drinkers age 21 60
* Healthy right-handed adult light drinkers age 21 60

Design:

* Participants will be screened with medical history, physical exam, and blood and urine tests. They will have an EKG and psychiatric interview.
* Participants will have one or two clinic visits.
* Participants will be asked about their alcohol drinking.
* They will choose a snack and alcoholic beverage that they must drink in 5 minutes. After their breath alcohol content (BrAC) is zero, they will play a game in the MRI scanner.
* The scanner is a metal cylinder that takes pictures of the brain. Participants lie on a table that slides in and out of the cylinder. They will be in it for about 90 minutes, lying still for up to 20 minutes.
* During the MRI, participants will play a simple computer game to earn food or drink points under different threats of electric shock. Points can be exchanged for food or alcohol after the game. Sometimes, participants will receive a mild electric shock through a metal disk on the wrist. Electric shocks will only happen if the participant tries to earn a reward point.
* After the MRI, participants use their points for another drink and snack. They will stay at the clinic until their BrAC is low, usually within 3 hours. Participants cannot drive themselves home.
* Participants will have a follow-up phone call the next day.

Conditions

  • Alcoholism
  • fMRI
  • Rewarding Mediating System

Sponsors & Collaborators

  • National Institute on Alcohol Abuse and Alcoholism (NIAAA)

    lead NIH

Principal Investigators

  • Reza Momenan, Ph.D. · National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Eligibility

Min Age
21 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-07-23
Primary Completion
2020-09-01
Completion
2020-09-01

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02119624 on ClinicalTrials.gov