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Human Alcohol Seeking Despite Aversion

NCT03648840 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 84

Last updated 2025-02-25

Study results available
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Summary

Prolonged alcohol use results in drinking despite resultant problems and adverse consequences. The investigators propose to test a laboratory model of human seeking despite aversion to use as an early marker of disease onset, and as a tool for study of its neural functional substrates, and identification of effective treatments.

Conditions

  • Alcohol Abuse

Interventions

BEHAVIORAL

Aversive Cue

Participants will be exposed to unpleasant pictures and tones during performance of a task to earn alcohol

BEHAVIORAL

Neutral Cue

Participants will be exposed to neutral pictures and tones during performance of a task to earn alcohol

Sponsors & Collaborators

  • Purdue University

    collaborator OTHER

  • National Institute on Alcohol Abuse and Alcoholism (NIAAA)

    collaborator NIH

  • Indiana University

    lead OTHER

Principal Investigators

  • Martin H Plawecki, MD, PhD · Psychiatry, Indiana University School of Medicine

  • Melissa A Cyders, PhD · Psychology, Indiana University-Purdue University at Indianapolis

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
21 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-04-04
Primary Completion
2022-05-04
Completion
2022-05-04

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03648840 on ClinicalTrials.gov