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Characterization Imaging Instruments in Alcoholics and Non-Alcoholics

NCT02108080 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 1000

Last updated 2026-05-22

No results posted yet for this study

Summary

Background:

\- People with alcoholism have differences in their brains compared with healthy people. People who are dependent on alcohol also perform differently on behavioral tasks. Researchers want to find out more about these differences. They also want to see if these differences are related to DNA.

Objective:

\- To see if differences in brain structure relate to personality and behavior differences in people with and without alcohol dependence.

Eligibility:

\- Adults age 18 and older.

Design:

* Participants will visit the NIH Clinical Center once during the study.
* Participants will be screened with a medical history, EKG, and physical exam. They will give blood and urine samples and undergo a psychiatric interview.
* Participants will be asked about their alcohol drinking, to see if they have an alcohol use disorder.
* Participants will play three computerized games. Some will play these games inside a magnetic resonance imaging (MRI) scanner.
* MRI: strong magnetic field and radio waves take pictures of the brain. Participants lie on a table that slides in and out of a cylinder. They will be in the scanner for about 90 minutes. They may lie still for up to 20 minutes at a time. The scanner makes loud knocking noises. They will get earplugs.

Conditions

  • Alcohol Dependence
  • Alcohol Drinking
  • Alcohol-Related Disorders
  • Alcoholism
  • Brain Mapping

Sponsors & Collaborators

  • National Institute on Alcohol Abuse and Alcoholism (NIAAA)

    lead NIH

Principal Investigators

  • Nancy Diazgranados, M.D. · National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-07-10
Primary Completion
2026-12-31
Completion
2026-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02108080 on ClinicalTrials.gov