Progression of Coronary Atherosclerosis in Asymptomatic Diabetic Subjects

Summary

The purpose of the study is to identify a sub-group of diabetic patients at higher risk of progression of coronary disease and also more likely to suffer from heart attack/angina and heart failure. The total number of patients to be recruited in this study will be 250 with type-2 diabetes but no known heart disease. These patients will have an objective measure of the function of the lining of the arteries, CT scan of the arteries of the heart and an ultrasound scan of the heart and arteries of the neck done at baseline along with blood tests for identification new markers of malfunction of the lining and inflammation of the arteries. Patients will be followed up at 18 months. During the follow-up visit, in addition to the blood tests, the CT scan of the heart arteries and ultrasound of the heart and arteries of the neck will be repeated to assess progression of the non-calcified, calcified and mixed plaques in the coronary arteries.

Conditions

• Type 2 Diabetes
• Coronary Artery Disease

Sponsors & Collaborators

• Royal Free Hospital NHS Foundation Trust

  collaborator OTHER

• London North West Healthcare NHS Trust

  collaborator OTHER

• Barnet and Chase Farm Hospitals NHS Trust

  collaborator OTHER

• Diabetes and Obesity Research Network

  collaborator NETWORK

• Lund University

  collaborator OTHER

• Health Diagnostic Laboratory, Inc.

  collaborator INDUSTRY

• British Cardiac Research Trust

  lead OTHER

Principal Investigators

• Roby Rakhit, MD FRCP · Royal Free Hospital NHS Foundation Trust

• Avijit Lahiri, MRCP FACC · Wellington Hospital

• Daniel Darko, MRCP · Central Middlesex Hospital

• Mark Cohen, PhD FRCP · Barnet Hospital

• Rajiv A Amersey, MD FRCP · Whipps Cross Hospital

• Sarita Naik, DM MRCP · University College London Hospital

Eligibility

Min Age

35 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2012-09-30

Primary Completion

2015-07-31

Completion

2017-07-31

Countries

• United Kingdom

Study Locations