Trial Investigating the Effect of Semaglutide on Energy Intake, Appetite Sensations, Postprandial Glucose and Triglyceride Metabolism and Gastric Emptying in Obese Subjects Compared With Placebo
NCT02079870 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 30
Last updated 2017-12-02
Summary
This trial is conducted in Europe. The aim of the trial is to investigate the effect of semaglutide on energy intake, appetite sensations, postprandial glucose and triglyceride metabolism and gastric emptying in obese subjects compared with placebo.
Conditions
Interventions
- DRUG
-
Solution for subcutaneous (s.c. - under the skin) injection. 0.25 mg semaglutide once weekly for four weeks, 0.5 mg semaglutide once weekly for four weeks followed by 1.0 mg semaglutide once weekly for five weeks
- DRUG
-
Solution for subcutaneous (s.c. - under the skin) injection
Sponsors & Collaborators
- lead INDUSTRY
Principal Investigators
-
Global Clinical Registry (GCR, 1452) · Novo Nordisk A/S
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- DOUBLE
- Model
- CROSSOVER
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2014-03-06
- Primary Completion
- 2015-01-07
- Completion
- 2015-01-07
Countries
- United Kingdom
Study Locations
More Related Trials
-
Effect of Food on the Pharmacokinetics of Oral Semaglutide in Healthy Subjects
NCT02172313 ·Status: COMPLETED ·Phase: PHASE1
-
A Research Study to Look at How Semaglutide Affects Gastric Emptying in People With Obesity
NCT03842202 ·Status: COMPLETED ·Phase: PHASE1
-
A Randomised Controlled Clinical Trial in Type 2 Diabetes Comparing Semaglutide to Placebo and Liraglutide
NCT00696657 ·Status: COMPLETED ·Phase: PHASE2
-
A Trial to Assess the Effect of Liraglutide on Gastric Emptying in Healthy Obese Volunteers
NCT00978393 ·Status: COMPLETED ·Phase: PHASE1
-
Investigation on Safety, Tolerability and Pharmacokinetics of Single and Multiple Doses of a Long-acting GLP-1 Analogue (Semaglutide) in an Oral Formulation in Healthy Male Subjects
NCT01866748 ·Status: COMPLETED ·Phase: PHASE1
-
Research Study Looking at How Well Semaglutide Works in People Living With Obesity and Prediabetes
NCT05040971 ·Status: COMPLETED ·Phase: PHASE3
-
Efficacy and Safety of Oral Semaglutide Versus Liraglutide and Versus Placebo in Subjects With Type 2 Diabetes Mellitus
NCT02863419 ·Status: COMPLETED ·Phase: PHASE3
-
Investigation of Optimal Dosing Conditions for a Long Acting GLP-1 Analogue in Healthy Male Subjects
NCT01572753 ·Status: COMPLETED ·Phase: PHASE1
-
Efficacy and Safety of Oral Semaglutide Versus Placebo in Subjects With Type 2 Diabetes Mellitus Treated With Diet and Exercise Only
NCT02906930 ·Status: COMPLETED ·Phase: PHASE3
-
A Research Study of NNC0165-1875 Alone or Together With Semaglutide in People Who Are Overweight or Obese
NCT03707990 ·Status: COMPLETED ·Phase: PHASE1
-
Investigating the Pharmacokinetics, Safety and Tolerability After a Single Subcutaneous Injection of Semaglutide in Subjects With Mild, Moderate or Severe Hepatic Impairment Compared to Subjects With Normal Hepatic Function
NCT02210871 ·Status: COMPLETED ·Phase: PHASE1
-
A Research Study to Look at How CagriSema Influences Food Intake, Appetite and Emptying of the Stomach in People With Excess Body Weight
NCT06207877 ·Status: COMPLETED ·Phase: PHASE1
-
Dose-response, Safety and Efficacy of Oral Semaglutide Versus Placebo and Versus Liraglutide, All as Monotherapy in Japanese Subjects With Type 2 Diabetes
NCT03018028 ·Status: COMPLETED ·Phase: PHASE3
-
A Trial to Assess the Pharmacokinetics, Safety and Tolerability of Semaglutide in Healthy Chinese Subjects
NCT03288740 ·Status: COMPLETED ·Phase: PHASE1
-
Effect of Liraglutide Compared to Glimepiride on Appetite in Subjects With Type 2 Diabetes
NCT01511692 ·Status: COMPLETED ·Phase: PHASE1
-
GLP-1 Analogue Effects on Food Cues, Stress, Motivation for Highly Palatable Foods, and Weight
NCT04779697 ·Status: COMPLETED ·Phase: PHASE1
-
Effect of Liraglutide on Pulsatile Insulin Secretion in Subjects With Type 2 Diabetes
NCT01507311 ·Status: COMPLETED ·Phase: PHASE1
-
First Research Study to Look at How Two Medicines, NNC0480-0389 and Semaglutide, Work Together in Healthy People, in People With High Body Weight and in People With Diabetes
NCT04259801 ·Status: COMPLETED ·Phase: PHASE1
-
A Research Study Looking at How 50 mg Semaglutide Daily Affects Food Intake and Emptying of the Stomach in People With Obesity
NCT05236517 ·Status: COMPLETED ·Phase: PHASE1
-
A Research Study of How NNC0174-0833 Taken With Semaglutide Works in People Who Are Overweight or Obese
NCT03600480 ·Status: COMPLETED ·Phase: PHASE1
-
A Research Study Comparing a New Medicine Oral Semaglutide to Placebo in People With Type 2 Diabetes
NCT04109547 ·Status: COMPLETED ·Phase: PHASE3
-
Research Study Investigating How Well Semaglutide Works in People With Type 2 Diabetes Suffering From Overweight or Obesity
NCT03552757 ·Status: COMPLETED ·Phase: PHASE3
-
The Effect of Weekly Semaglutide Treatment on Energy Expenditure
NCT06390501 ·Status: COMPLETED ·Phase: NA
-
STEP 6: Research Study Investigating How Well Semaglutide Works in People Living With Overweight or Obesity
NCT03811574 ·Status: COMPLETED ·Phase: PHASE3
-
A Clinical Trial Comparing Semaglutide in Healthy People Who Eat and Take the Medicine at Different Times
NCT04513704 ·Status: COMPLETED ·Phase: PHASE1