Optimizing Exercise Training in Prevention and Treatment of Diastolic Heart Failure

Summary

Aim of the clinical multicenter study (OptimEx-CLIN) is to assess the optimal exercise intervention in patients with Heart Failure with preserved Ejection Fraction (HFpEF; also termed diastolic heart failure) that will best improve peak oxygen uptake (Peak Vo2) and additionally diastolic function (assessed echocardiographically). The investigators hypothesize that exercise training reverses HFpEF and that intensity of exercise training is more important than duration.

Conditions

• Heart Failure With Preserved Ejection Fraction

Interventions

BEHAVIORAL

High Intensity Exercise

BEHAVIORAL

Moderate Continuous Exercise

BEHAVIORAL

Usual Care

Sponsors & Collaborators

• European Commission

  collaborator OTHER

• University of Leipzig

  collaborator OTHER

• University Hospital, Antwerp

  collaborator OTHER

• Medical University of Graz

  collaborator OTHER

• Norwegian University of Science and Technology

  collaborator OTHER

• Charite University, Berlin, Germany

  collaborator OTHER

• Technical University of Munich

  lead OTHER

Principal Investigators

• Martin Halle, M.D. · Technische Universität München, Munich, Germany

• Martin Halle, M.D. · Technische Universität München, Munich, Germany

• Burkert Pieske, M.D. · Charite University, Berlin, Germany

• Christiaan Vrints, M.D. · Antwerp University Hospital, Belgium

• Volker Adams, Ph.D. · Heart Center Leipzig, Leipzig, Germany

• Ulrik Wisløff, Ph.D. · Norwegian University of Science and Technology, Trondheim, Norway

• Axel Linke, M.D. · Heart Center Leipzig, Leipzig, Germany

• Frank Edelmann, M.D. · Charite University, Berlin, Germany

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

40 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2014-07-28

Primary Completion

2017-09-30

Completion

2018-06-27

Countries

• Belgium
• Germany

Study Locations