MedTrace Logo

Airway Inflammatory Response During Illness in Children With Respiratory Failure

NCT02047877 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2017-11-14

No results posted yet for this study

Summary

The purpose of this study has two major goals: 1) to measure the amount of two specific hormones interleukin (IL)-10 and interleukin (IL)-12p70 in mucous and blood; and 2) compare the hormone levels in two specific areas of the lung called the trachea (upper airway) and the bronchioles (lower airway). The hormones IL-10 and IL-12p70 are cytokines, special hormones cells use to communicate with each other during inflammation or infection. Cytokines can be measured in mucous and blood. The balance of one cytokine compared to another help doctors to understand how people respond differently to infection. Unfortunately, the amount of IL-10 and IL-12p70 is not known in children, especially children with a lung infection. In addition, we do not know if the balance of these cytokines differ in various regions of the lung. We believe the balance of IL-10 and IL-12p70 is similar whether measured in the upper or lower airways.

Conditions

  • Acute Respiratory Failure
  • Acute Respiratory Infection
  • Acute Respiratory Distress Syndrome

Sponsors & Collaborators

  • University of North Carolina, Chapel Hill

    lead OTHER

Principal Investigators

  • Daniel Lercher, MD · University of North Carolina Hospital at Chapel Hill

  • Benny Joyner, MD, MPH · University of North Carolina, Chapel Hill

  • Benny L Joyner, Jr., MD, MPH · University of North Carolina, Chapel Hill

Eligibility

Max Age
17 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-07-31
Primary Completion
2019-08-31
Completion
2019-08-31

Countries

  • United States

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02047877 on ClinicalTrials.gov