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Cultures in PICU Patients Compared to Healthy Children

NCT03418272 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2022-04-22

No results posted yet for this study

Summary

This study is being done to determine if the bacteria found in your mouth (oral flora bacteria) in children admitted to the intensive care unit who need to be on a breathing machine is different from the oral flora in healthy children undergoing anesthesia for their dental caries. Children in the intensive care unit with a breathing tube are at a higher risk for getting a lung infection due to the bacteria in the mouth slipping into their lungs past the breathing tube over several days. This means that bacteria are found in the child's lung when this is normally not the case. If the bacteria in the mouth have changed from normal then they may get a pneumonia.

Conditions

  • Ventilator Associated Pneumonia
  • Pneumonia, Bacterial

Interventions

DIAGNOSTIC_TEST

Culture/PCR Analysis

Microbes to be selectively cultured and PCR analysis to be conducted. Bacteria obtained in samples will be dispersed in non-selective Mueller Hinton Broth (Sigma-Aldrich), divided into two separate cultures and grown overnight at 37°C in aerobic condition and in 5% CO2 to assure survival of both aerobic and facultative anaerobic species. * Staphylococcus aureus (MSSA, MRSA) * Pseudomonas aeruginosa * Haemophilus influenza * Streptococcus pneumonia * Streptococcus Pyogenes Group B streptococci, * Klebsiella pneumonia * Moraxella catarrhalis

Sponsors & Collaborators

  • State University of New York at Buffalo

    lead OTHER

Principal Investigators

  • Christopher Heard, MBChB, FRCA · Jacobs School of Medicine

Eligibility

Min Age
2 Years
Max Age
8 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-02-28
Primary Completion
2023-05-31
Completion
2023-09-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03418272 on ClinicalTrials.gov