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Possible Relation of Toll-Like Receptors and Nitric Oxide to Chronic Lung Disease

NCT00245167 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 120

Last updated 2016-07-29

No results posted yet for this study

Summary

The first objective of this study is to determine if increased expression of one or more members of the toll-like receptor (TLR) family of receptors that are found on inflammatory cells (present in the airway) precede development of chronic lung disease (CLD) of prematurity. The study will also determine if there is a significant correlation between TLRs and the severity of CLD. The second objective of this study is to determine the impact of c-administration of inhaled nitric oxide (INO) on TLR expression in infants at risk of developing CLD or with early CLD.

Conditions

  • Lung Diseases

Interventions

PROCEDURE

Tracheal Aspirate Fluid

Sponsors & Collaborators

  • National Heart, Lung, and Blood Institute (NHLBI)

    lead NIH

Principal Investigators

  • William E. Troug, MD · Children's Mercy Hospital & Clinic

Eligibility

Max Age
1 Year
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2002-01-31
Primary Completion
2006-05-31
Completion
2006-05-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00245167 on ClinicalTrials.gov