Linking Endotypes and Outcomes in Pediatric Acute Respiratory Distress Syndrome

Summary

The overall goal of the study is to risk stratify pediatric Acute Respiratory Distress Syndrome (ARDS) patients and to identify sub-phenotypes with shared biology in order to appropriately target therapies in future trials. This is a prospective, multicenter study of 500 intubated children with ARDS, with planned blood collection within 24 hours of ARDS onset and subsequent measurement of plasma protein biomarkers and peripheral blood gene expression.

Conditions

• Acute Respiratory Distress Syndrome

Sponsors & Collaborators

• Akron Children's Hospital

  collaborator OTHER

• Children's Hospital and Health System Foundation, Wisconsin

  collaborator OTHER

• Children's Hospital Medical Center, Cincinnati

  collaborator OTHER

• Children's Mercy Hospital Kansas City

  collaborator OTHER

• Milton S. Hershey Medical Center

  collaborator OTHER

• Nationwide Children's Hospital

  collaborator OTHER

• Nicklaus Children's Hospital

  collaborator UNKNOWN

• Indiana University

  collaborator OTHER

• Cooperman Barnabas Medical Center

  collaborator UNKNOWN

• Baylor College of Medicine

  collaborator OTHER

• Columbia University

  collaborator OTHER

• National Heart, Lung, and Blood Institute (NHLBI)

  collaborator NIH

• Arkansas Children's Hospital Research Institute

  collaborator OTHER

• Children's Healthcare of Atlanta

  collaborator OTHER

• Children's Hospital Colorado

  collaborator OTHER

• Washington University School of Medicine

  collaborator OTHER

• Children's Hospital of Philadelphia

  lead OTHER

Principal Investigators

• Nadir Yehya, M.D. · Children's Hospital of Philadelphia

Eligibility

Min Age

44 Weeks

Max Age

17 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2020-01-07

Primary Completion

2025-02-15

Completion

2025-04-01

Countries

• United States

Study Locations