Study to Determine the Impact of Intraoperative Blood Pressure Management on Postoperative Outcomes (MAP-ALIVE)

Summary

The purpose of this study is to determine

1. whether intraoperative hypotension or hypertension is independently associated with postoperative mortality and morbidity
2. whether quality improvement interventions implemented at the University of Michigan and at Washington University:

1. decrease the extent and duration of intraoperative hypotension and hypertension.
2. are associated with decreased postoperative mortality and morbidity.

Conditions

• Death
• Postoperative Complications
• Myocardial Infarction
• Stroke
• Renal Failure

Interventions

OTHER

FACE quality improvement initiative (see below)

Feedback (F): Regular feedback to practitioners; MAP Alerts (A): Change in electronic alert systems for high and low mean arterial pressure with patient specific alerts; Checklist (C): Interactive checklist in relation to the quality improvement initiative; Education campaign (E): Education campaigns about best intraoperative management of blood pressure.

OTHER

Pre-quality improvement initiative

Patients in the pre-quality improvement initiative arm would receive current standard practice.

Sponsors & Collaborators

• University of Michigan

  collaborator OTHER

• Washington University School of Medicine

  lead OTHER

Principal Investigators

• Michael S Avidan, MBBCh · Washington University School of Medicine

• Sachin Kheterpal, MD · University of Michigan

• Alex S Evers, MD · Washington University School of Medicine

• Kevin Tremper, MD PhD · University of Michigan

• Anshuman Sharma, MD · Washington University School of Medicine

• Dan Helsten, MD · Washington University School of Medicine

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2011-06-30

Primary Completion

2014-01-31

Completion

2014-01-31

Countries

• United States

Study Locations