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Anti-histamines and Methacholine Challenges.

NCT01985789 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2015-04-08

No results posted yet for this study

Summary

The asthmatic airway is identified and studied using inhaled agents such as histamine and methacholine. The use of antihistamines prior to the test will inhibit the test result if histamine is used to cause airway constriction. If using methacholine, this may also be true depending on whether old (e.g. benadryl) or new (e.g. desloratadine) antihistamines are used. This study will look at the effect of old and new antihistamines on inhaled methacholine challenge response in individuals with mild asthma.

Conditions

Interventions

DRUG

Diphenhydramine

DRUG

cetirizine

DRUG

desloratadine

DRUG

placebo

Sponsors & Collaborators

  • Don Cockcroft

    lead OTHER

Principal Investigators

  • Donald W Cockcroft, MD · University of Saskatchewan, Department of Medicine, Division of Respirology, Critical Care and Sleep Medicine

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-11-30
Primary Completion
2014-05-31
Completion
2014-05-31

Countries

  • Canada

Study Locations

More Related Trials

Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01985789 on ClinicalTrials.gov