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Effects of MSPrebiotic on Gut Health in the Elderly

NCT01977183 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 84

Last updated 2023-01-06

No results posted yet for this study

Summary

The purpose of this clinical trial is to study the effects of potato resistant starch on the microbiota (microorganisms or bacteria) and short chain fatty acids levels of the gut. Levels will be measured and compared between elderly adults and in pre-elderly, adults from the general public. A correlation between the use of potato resistant starch and specific clinical and quality of life endpoints between elderly adults and in pre-elderly, adults from the general public will be studied.

Hypothesis 1: The investigator hypothesizes that the microbiome in elderly adults (≥70 years) is less diverse and more prone to imbalance compared to adults (30-50 years) from the general population and that this imbalance of the gut microflora in the elderly adults is partially related to inadequate RS in their diet.

Hypothesis 2: The investigator hypothesizes that ingestion of potato resistant starch of food grade quality (MSPrebiotic) will stabilize the gut microbiome (i.e. high Firmicutes/Bacteroides ratio)in LTC residents (i.e. similar to that of adults from the general population), thereby improving gut health and reducing the risk of diarrhea and/or gut infection.

Conditions

  • Focus of Study; Impact of MSPrebiotic on Gastrointestinal Microbiota

Interventions

DIETARY_SUPPLEMENT

MSPrebiotic

Potato Resistant Starch

DIETARY_SUPPLEMENT

Placebo

Placebo - Corn Starch

Sponsors & Collaborators

  • National Microbiology Laboratory, Canada

    collaborator OTHER

  • MSP Starch Products Inc.

    collaborator INDUSTRY

  • St. Boniface Hospital

    lead OTHER

Principal Investigators

  • Michelle J Alfa, PhD · St. Boniface Hospital Research Centre

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
30 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-09-30
Primary Completion
2016-01-31
Completion
2016-06-30

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01977183 on ClinicalTrials.gov