Effects of Fructan Prebiotics on the Intestinal Microbiota

Summary

Prebiotics are carbohydrate polymers believed to improve health by stimulating beneficial gastrointestinal microbial populations. Prebiotic health claims are currently not permitted in Canada due to a lack of validating scientific data. Currently, Health Canada considers 'prebiotic' to imply a health benefit that must be substantiated. Our goal is to conduct a human clinical trial to define the impacts of fructans on the colonic microbiome as well as the physiological, psychological and immunological effects on the host.

Conditions

• Study Focus is to Define the Usual Gut Microbiota Following Prebiotic Feeding

Interventions

DIETARY_SUPPLEMENT

Prebiotic

Inulin-fructan 15mg/day for 28days

DIETARY_SUPPLEMENT

Prebiotic

Daily consumption of 15g inulin-fructan for 28 days

Sponsors & Collaborators

• Health Canada

  collaborator OTHER_GOV

• Advance Foods and Materials Network

  collaborator OTHER

• University of Ontario Institute of Technology

  collaborator OTHER

• University of Lethbridge

  collaborator OTHER

• Dan Ramdath

  lead OTHER_GOV

Principal Investigators

• Dan Ramdath, PhD · Guelph Food Research Centre

• Martin Kalmokoff, PhD · Agriculture and Agri-Food Canada

• Steven Traplin, MD · Nutrasource Diagnostic Inc

• Maggie Laidlaw, PhD · Nutrasource Diagnostic Inc

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Max Age

50 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2011-01-31

Primary Completion

2011-03-31

Completion

2013-03-31

Countries

• Canada

Study Locations