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Executive Reaction Time Test in Assessment of Cognitive Dysfunction After Aortic Valve Procedures

NCT01953068 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 18

Last updated 2021-04-08

No results posted yet for this study

Summary

Up to 50% of patients undergoing surgical aortic valve operation suffer from some level of post-operative cognitive dysfunction (POCD). Frontal lobes of the brain, where executive functions are located, are highly susceptible to trauma caused by possible blood malperfusion to these areas of the brain during surgery. Conventional and established neuropsychological test methods are poor in distinguishing these kinds of trauma, as they are isolated, structured tests that do not require multitasking and processing of multiple stimuli at the same time.

The phase 1 goal of this study is to employ an experimental Executive reaction time (RT) test to see if this method could improve objective detection of subtle brain dysfunction assumed to underlie persistent cognitive, somatic, and affective complaints reported by patients who have undergone electic aortic valve replacement (AVR) surgery. Phase 2 of the study will concentrate on patients undergoing transcatheter aortic valve implantation (TAVI).

Conditions

  • Neurobehavioral Manifestations

Sponsors & Collaborators

  • Tampere University Hospital

    lead OTHER

Principal Investigators

  • Jonne Liimatainen, MD · Tampere University Hospital

  • Kaisa Hartikainen, Professor · Behavioral Neurology Research Unit, Pirkanmaa Hospital District

  • Arvi Yli-Hankala, Professor · Tampere University Hospital

  • Kati Järvelä, MD, PhD · Tampere University Hospital Heart Center

Eligibility

Min Age
60 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-01-31
Primary Completion
2016-05-31
Completion
2016-05-31

Countries

  • Finland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01953068 on ClinicalTrials.gov