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Imaging and Genetic Investigation of Learning and Decision Making

NCT01950377 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 78

Last updated 2022-01-24

No results posted yet for this study

Summary

Background:

\- Previous research has shown that dopamine, a brain chemical, is involved in decision making. Different genes influence how much dopamine people have in their brains and how that affects their behavior. Researchers will study if genes associated with dopamine affect decision making and impulsiveness. All participants will take tests; some will have brain images taken. Researchers will study the test responses and images; they will look for how differences in these genes affect different types of decision making.

Objectives:

\- To see if genes involved in a brain chemical, dopamine, are related to impulsiveness on behavioral tests.

Eligibility:

\- Healthy adults ages 18 to 55.

Design:

* Participants will be screened with a medical history and physical exam.
* All participants in this study will have at least 1 outpatient visit to the NIH Clinical Center. Each visit will last 2 4 hours. At the first visit:
* A blood sample will be taken only from participants that have not been previously enrolled in 95-M-0150
* Participants will be given tests of their memory, attention, concentration, and thinking.
* Some participants will have a second visit. It will be scheduled as soon as possible after the first. At the second visit:
* Participants will have an MRI (magnetic resonance imaging). They will have to lie in a scanner for up to 2 hours. The MRI uses magnets, radio waves, and computers to produce detailed pictures of the brain.
* Participants will repeat the tests from the first visit. Some will be done during the MRI.

Conditions

  • Polymorphism- Genetic
  • Reward Mediating System

Sponsors & Collaborators

  • National Institute of Mental Health (NIMH)

    lead NIH

Principal Investigators

  • Bruno B Averbeck, Ph.D. · National Institute of Mental Health (NIMH)

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-02-11
Primary Completion
2018-02-10
Completion
2020-03-05

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01950377 on ClinicalTrials.gov