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Comparison of Standard ART Practice vs. Trophectoderm Biopsy and Whole Chromosome Analysis

NCT01946945 · Status: UNKNOWN · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 240

Last updated 2014-09-09

No results posted yet for this study

Summary

We propose to perform a clinical randomized trial to evaluate the effect of blastocyst biopsy and whole chromosome analysis by Next Generation Sequencing (NGS) in comparison to standard Assisted Reproductive Technologies (ART) methods on on implantation rates, miscarriage rates, and pregnancy rates.

This will be three studies into one: a) a comparison of treatment (NGS) and no treatment, b) a non-selection study based on the control group for which we will replace without knowing the ploidy of the embryos, but we will know it later, c) a retrospective study about the use of Mitochondrial DNA as a selection tool.

Conditions

Interventions

GENETIC

Next Generation Sequencing after Blastocyst biopsy

PGD using blastocyst biopsy and testing of the biopsy by NGS

Sponsors & Collaborators

  • Main Line Fertility Center

    collaborator OTHER

  • Reprogenetics

    lead INDUSTRY

Principal Investigators

  • Santiago Munne, PhD · Reprogenetics

Study Design

Allocation
RANDOMIZED
Purpose
SCREENING
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
42 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-09-30
Primary Completion
2014-12-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01946945 on ClinicalTrials.gov