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Effect of Varied Dialysate Bicarbonate Levels on Phosphate and Potassium Removal

NCT01930370 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2015-05-28

No results posted yet for this study

Summary

Modeling of bicarbonate within the dialysate fluid, specifically a lower than standard concentration has been suggested in facilitating the removal of phosphate and potassium. To test this hypothesis, the study will use a cross-over study design to evaluate phosphate and potassium removal during dialysis by altering bicarbonate concentration in dialysis fluid (i.e. high bicarbonate, standard bicarbonate washout, low bicarbonate), and compare the effects of the different dialysate bicarbonate concentrations on the removal of phosphate and potassium during hemodialysis

Conditions

  • Chronic Dialysis Patients

Interventions

DRUG

Bicarbonate hemodialysis solution (low concentration)

One-week experimental session (3 dialysis treatments) with low dialysate bicarbonate (28 mmol/L)

DRUG

Bicarbonate hemodialysis solution (high concentration)

One-week experimental session with high dialysate bicarbonate (38 mmol/L)

Sponsors & Collaborators

  • The Hospital for Sick Children

    lead OTHER

Principal Investigators

  • Denis Geary, MD · The Hospital for Sick Children

Study Design

Purpose
TREATMENT
Masking
NONE
Model
CROSSOVER

Eligibility

Max Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-03-31
Primary Completion
2014-07-31
Completion
2014-12-31

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01930370 on ClinicalTrials.gov