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Increased Activity of a Renal Salt Transporter (ENaC) in Diabetic Kidney Disease

NCT01918488 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2013-10-16

No results posted yet for this study

Summary

The purpose of the study is to determine whether a diuretic drug called amiloride is capable of increasing renal salt excretion and thereby decrease blood pressure in diabetic patients with kidney disease. Our hypothesis states that amiloride is capable of reducing blood pressure in these patients and thus decrease the cardiovascular risk associated with diabetic kidney disease.

Conditions

Interventions

DIETARY_SUPPLEMENT

Standardized salt diet

200 mmol NaCl per day given as three meals daily for 4 consecutive days.

DRUG

Amiloride

Amiloride tablet 20 mg two times daily (morning and afternoon) for two consecutive days.

Sponsors & Collaborators

  • Odense University Hospital

    collaborator OTHER

  • Region of Southern Denmark

    collaborator OTHER

  • The Ministry of Science, Technology and Innovation, Denmark

    collaborator OTHER_GOV

  • Danish Heart Foundation

    collaborator OTHER

  • University of Southern Denmark

    lead OTHER

Principal Investigators

  • Henrik Andersen, MD · University of Southern Denmark

  • Jan Erik Henriksen, MD, PhD · Odense University Hospital

  • Claus Bistrup, MD, PhD · Odense University Hospital

  • Boye L Jensen, MD, PhD · University of Southern Denmark

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-10-31
Primary Completion
2014-12-31

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01918488 on ClinicalTrials.gov