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Mechanistic Prehabilitation

NCT01919541 · Status: WITHDRAWN · Phase: NA · Type: INTERVENTIONAL

Last updated 2018-03-22

No results posted yet for this study

Summary

The investigators hypothesize that individuals who receive a personalized 4 week prehabilitation program consisting of exercise and nutrition counselling with post-workout whey protein supplementation will show, before colorectal surgery, improved insulin sensitivity, inflammatory profile, and substrate utilization compared to baseline measures. These results will translate into a higher functional capacity before surgery as demonstrated by an improvement in 6-minute walking test.

Conditions

Interventions

OTHER

Prehabilitation

All patients will receive a prehabilitation program, which involves a personalized exercise component provided by a kinesiologist.

DEVICE

hyperinsulinemic euglycemic isoaminoacid clamp

A hyperinsulinemic euglycemic isoaminoacid clamp followed by a hyperinsulinemic euglycemic hyperaminoacid clamp performed at baseline and immediately before surgery will provide insight into insulin resistance of glucose and protein metabolism in colorectal cancer patients pre- and post-intervention. Similarly, simultaneous infusions of leucine and glucose stable isotopes will provide insight into baseline and interventional effects of the program on whole body leucine and glucose kinetics.

DEVICE

hyperinsulinemic euglycemic hyperaminoacid clamp

DIETARY_SUPPLEMENT

whey protein supplementation

OTHER

Prehabilitation

All patients will receive nutrition guidance and a nutrition component with whey protein supplementation.

Sponsors & Collaborators

  • Franco Carli

    lead OTHER

Principal Investigators

  • Franco Carli, MD · McGill University Health Centre/Research Institute of the McGill University Health Centre

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-12-31
Primary Completion
2016-12-31
Completion
2016-12-31

Countries

  • Canada

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01919541 on ClinicalTrials.gov