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Preoperative Prehabilitation for Sarcopenic Patients Prior to Pancreatic Surgery for Cancer

NCT04469504 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 158

Last updated 2026-05-20

No results posted yet for this study

Summary

Major digestive surgery is associated with a significant rate of postoperative complications. To improve postoperative outcome, efforts are focused on postoperative course leading to the concept of rehabilitation. However, the rehabilitation concept does not allow to improve muscular and functional reserves at the time of surgery. Sarcopenia is a condition characterized by loss of skeletal muscle mass and function. Also, the prevalence of sarcopenia in patients with cancer is high and has a prevalence of around 25% in patients with pancreatic cancer, with a considerable impact on postoperative and survival outcomes.

The hypothesis is the preoperative management of sarcopenia by a rehabilitation program could improve patients' operative outcomes by reducing the rate of postoperative complications.

Conditions

Interventions

OTHER

Prehabilitation program

4-week trimodal prehabilitation program: Exercise, nutritional supplementation, and psychological support

DIETARY_SUPPLEMENT

Oral Impact

perioperative immunonutrition by ORAL IMPACT

Sponsors & Collaborators

  • Groupement Interrégional de Recherche Clinique et d'Innovation

    collaborator OTHER

  • Santelys Association

    collaborator OTHER

  • University Hospital, Lille

    lead OTHER

Principal Investigators

  • Mehdi ELAMRANI, MD · University Hospital, Lille

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-05-17
Primary Completion
2028-05-31
Completion
2028-05-31

Countries

  • France

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04469504 on ClinicalTrials.gov