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Use of Cardiac-MRI to Predict Results for People With Severe Aortic Stenosis

NCT01905852 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2019-09-13

No results posted yet for this study

Summary

Background:

\- Aortic valve stenosis is a disease that makes a major heart valve get smaller. This reduces heart function and causes death. Severe aortic stenosis (AS) can be treated in a couple of ways, including replacing a heart valve.

Objectives:

Researchers want to study fibrosis in the heart. A sub-study will test whether heart function and blood supply improve after a valve replacement.

Eligibility:

\- Adults at least 18 years old with aortic stenosis.

Design:

* Participants will visit a clinic for 1 day for magnetic resonance imaging (MRI) of their heart. This uses magnets, radio waves, and computers to produce detailed pictures of the heart.
* After this visit, participants will have their aortic valve procedure at the the Washington Hospital Center. A hospital team will contact participants for 1 year by phone or email. This follow-up will consist of 15 minutes of questions about the participant s health status.
* Some participants will join a sub-study.
* They will be given an additional medication to evaluate the blood supply of the heart.
* They will visit a clinic for 1 day for an MRI of their heart, as part of the main study, prior to the aortic valve replacement.
* After they have their valve replaced at the hospital, they will return to the clinic for another MRI.
* They will have the same follow-up as in the main study.

Conditions

  • Aortic Valve Stenosis

Sponsors & Collaborators

  • Medstar Health Research Institute

    collaborator OTHER

  • National Heart, Lung, and Blood Institute (NHLBI)

    lead NIH

Principal Investigators

  • Andrew E Arai, M.D. · National Heart, Lung, and Blood Institute (NHLBI)

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-06-27
Primary Completion
2016-12-31
Completion
2016-12-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01905852 on ClinicalTrials.gov