CPT and Smoking Cessation

Summary

Posttraumatic stress disorder (PTSD) and cigarette smoking are both associated with significant impairment in Veterans and cost to the Veterans' Affairs (VA) system. Though research suggests smoking is linked with PTSD symptoms, existing smoking cessation treatments targeting PTSD smokers do not include PTSD treatment. The purpose of this study is to examine a treatment that combines evidence based treatment for PTSD (cognitive processing therapy, or CPT) with smoking cessation treatment for PTSD and a mobile text messaging program. The study objectives are to evaluate feasibility of the treatment and to examine effectiveness of CPT and smoking cessation treatment combined compared to smoking cessation treatment without CPT. Fifty Veteran smokers with PTSD will participate in fourteen study sessions, ending with the final follow-up session six months after the scheduled quit date.

Conditions

• Stress Disorders, Post-Traumatic
• Smoking

Interventions

BEHAVIORAL

Cognitive Processing Therapy (CPT)

CPT is based on a social cognitive theory of PTSD that includes primary emotional responses to traumatic events such as fear, anger, and sadness, as well as secondary emotions resulting from a patient's faulty interpretations of the traumatic event. CPT addresses PTSD by facilitating affective expression so that affective components of the trauma memory can be altered. In addition, faulty beliefs about the trauma are challenged and modified using Socratic questioning.

DRUG

Bupropion

Bupropion is an anti-depressant medication that is commonly used in smoking cessation treatment.

DRUG

nicotine replacement therapy (NRT)

NRT in the form of nicotine patches and an NRT rescue method (e.g., nicotine gum, lozenge, inhaler) will be prescribed for participants for use on/after quit date.

BEHAVIORAL

Integrated Care for Smoking Cessation (ICSC)

ICSC is a manualized treatment for smoking cessation involving six sessions of counseling.

BEHAVIORAL

smokefreeVET

SmokefreeVET is a program that was developed by the National Institutes of Health and Department of Veterans Affairs. The program includes a text messaging protocol for reaching out to Veterans who wish to stop smoking.

Sponsors & Collaborators

• VA Office of Research and Development

  lead FED

Principal Investigators

• Eric A Dedert, PhD · Durham VA Medical Center, Durham, NC

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2013-12-11

Primary Completion

2017-07-30

Completion

2017-07-30

FDA Drug

Yes

Countries

• United States

Study Locations